Gene Expression Literature Summary

Summary by Gene and Reference: Number indicates the number of results matching the search criteria recorded for each reference.
* Indicates detailed expression data entries available

Fgf8  fibroblast growth factor 8   (Synonyms: Aigf, Fgf-8)
Results	Reference
1	J:195145 Amaniti EM, Hasenpusch-Theil K, Li Z, Magnani D, Kessaris N, Mason JO, Theil T, Gli3 is required in Emx1(+) progenitors for the development of the corpus callosum. Dev Biol. 2013 Apr 15;376(2):113-24
1*	J:313619 Bedogni F, Hevner RF, Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development. Front Mol Neurosci. 2021;14:686034
1	J:160580 Borello U, Cobos I, Long JE, McWhirter JR, Murre C, Rubenstein JL, FGF15 promotes neurogenesis and opposes FGF8 function during neocortical development. Neural Dev. 2008;3:17
1	J:255068 Chan WK, Price DJ, Pratt T, FGF8 morphogen gradients are differentially regulated by heparan sulphotransferases Hs2st and Hs6st1 in the developing brain. Biol Open. 2017 Dec 15;6(12):1933-1942
1*	J:23136 Crossley PH, Martin GR, The mouse Fgf8 gene encodes a family of polypeptides and is expressed in regions that direct outgrowth and patterning in the developing embryo. Development. 1995 Feb;121(2):439-51
1*	J:153498 Diez-Roux G, Banfi S, Sultan M, Geffers L, Anand S, Rozado D, Magen A, Canidio E, Pagani M, Peluso I, Lin-Marq N, Koch M, Bilio M, Cantiello I, Verde R, De Masi C, Bianchi SA, Cicchini J, Perroud E, Mehmeti S, Dagand E, Schrinner S, Nurnberger A, SchmidtK, Metz K, Zwingmann C, Brieske N, Springer C, Hernandez AM, Herzog S, Grabbe F, Sieverding C, Fischer B, Schrader K, Brockmeyer M, Dettmer S, Helbig C, Alunni V, Battaini MA, Mura C, Henrichsen CN, Garcia-Lopez R, Echevarria D, Puelles E, et al., A high-resolution anatomical atlas of the transcriptome in the mouse embryo. PLoS Biol. 2011;9(1):e1000582
1	J:147878 Gao B, Hu J, Stricker S, Cheung M, Ma G, Law KF, Witte F, Briscoe J, Mundlos S, He L, Cheah KS, Chan D, A mutation in Ihh that causes digit abnormalities alters its signalling capacity and range. Nature. 2009 Apr 30;458(7242):1196-200
1	J:101176 Grieshammer U, Cebrian C, Ilagan R, Meyers E, Herzlinger D, Martin GR, FGF8 is required for cell survival at distinct stages of nephrogenesis and for regulation of gene expression in nascent nephrons. Development. 2005 Sep;132(17):3847-57
1*	J:21239 Heikinheimo M, Lawshe A, Shackleford GM, Wilson DB, MacArthur CA, Fgf-8 expression in the post-gastrulation mouse suggests roles in the development of the face, limbs and central nervous system. Mech Dev. 1994 Nov;48(2):129-38
1*	J:207609 Hilliard SA, Yao X, El-Dahr SS, Mdm2 is required for maintenance of the nephrogenic niche. Dev Biol. 2014 Mar 1;387(1):1-14
1	J:71074 Hirata H, Tomita K, Bessho Y, Kageyama R, Hes1 and Hes3 regulate maintenance of the isthmic organizer and development of the mid/hindbrain. EMBO J. 2001 Aug 15;20(16):4454-66
1	J:46744 Kettunen P, Thesleff I, Expression and function of FGFs-4, -8, and -9 suggest functional redundancy and repetitive use as epithelial signals during tooth morphogenesis. Dev Dyn. 1998 Mar;211(3):256-68
1*	J:29885 MacArthur CA, Lawshe A, Xu J, Santos-Ocampo S, Heikinheimo M, Chellaiah AT, Ornitz DM, FGF-8 isoforms activate receptor splice forms that are expressed in mesenchymal regions of mouse development. Development. 1995 Nov;121(11):3603-13
1*	J:28252 Mahmood R, Bresnick J, Hornbruch A, Mahony C, Morton N, Colquhoun K, Martin P, Lumsden A, Dickson C, Mason I, A role for FGF-8 in the initiation and maintenance of vertebrate limb bud outgrowth. Curr Biol. 1995 Jul 1;5(7):797-806
1*	J:103164 Minina E, Schneider S, Rosowski M, Lauster R, Vortkamp A, Expression of Fgf and Tgfbeta signaling related genes during embryonic endochondral ossification. Gene Expr Patterns. 2005 Dec;6(1):102-109
1	J:238726 Miyado M, Miyado K, Nakamura A, Fukami M, Yamada G, Oda SI, Expression patterns of Fgf8 and Shh in the developing external genitalia of Suncus murinus. Reproduction. 2017 Feb;153(2):187-195
1	J:196051 Moldrich RX, Gobius I, Pollak T, Zhang J, Ren T, Brown L, Mori S, De Juan Romero C, Britanova O, Tarabykin V, Richards LJ, Molecular regulation of the developing commissural plate. J Comp Neurol. 2010 Sep 15;518(18):3645-61
1	J:186888 Nagalakshmi VK, Ren Q, Pugh MM, Valerius MT, McMahon AP, Yu J, Dicer regulates the development of nephrogenic and ureteric compartments in the mammalian kidney. Kidney Int. 2011 Feb;79(3):317-30
1	J:78879 Pirvola U, Ylikoski J, Trokovic R, Hebert JM, McConnell SK, Partanen J, FGFR1 is required for the development of the auditory sensory epithelium. Neuron. 2002 Aug 15;35(4):671-80
1*	J:160766 Porntaveetus T, Oommen S, Sharpe PT, Ohazama A, Expression of Fgf signalling pathway related genes during palatal rugae development in the mouse. Gene Expr Patterns. 2010 Jun;10(4-5):193-8
1	J:110263 Smith KM, Ohkubo Y, Maragnoli ME, Rasin MR, Schwartz ML, Sestan N, Vaccarino FM, Midline radial glia translocation and corpus callosum formation require FGF signaling. Nat Neurosci. 2006 Jun;9(6):787-97
1	J:48144 Treier M, Gleiberman AS, O'Connell SM, Szeto DP, McMahon JA, McMahon AP, Rosenfeld MG, Multistep signaling requirements for pituitary organogenesis in vivo. Genes Dev. 1998 Jun 1;12(11):1691-704
1*	J:122989 Visel A, Thaller C, Eichele G, GenePaint.org: an atlas of gene expression patterns in the mouse embryo. Nucleic Acids Res. 2004 Jan 1;32(Database issue):D552-6
1*	J:90386 Wang CK, Omi M, Ferrari D, Cheng HC, Lizarraga G, Chin HJ, Upholt WB, Dealy CN, Kosher RA, Function of BMPs in the apical ectoderm of the developing mouse limb. Dev Biol. 2004 May 1;269(1):109-22
1	J:149542 Wang XP, O'Connell DJ, Lund JJ, Saadi I, Kuraguchi M, Turbe-Doan A, Cavallesco R, Kim H, Park PJ, Harada H, Kucherlapati R, Maas RL, Apc inhibition of Wnt signaling regulates supernumerary tooth formation during embryogenesis and throughout adulthood. Development. 2009 Jun;136(11):1939-49
1*	J:56088 Xu J, Lawshe A, MacArthur CA, Ornitz DM, Genomic structure, mapping, activity and expression of fibroblast growth factor 17. Mech Dev. 1999 May;83(1-2):165-78
1	J:61429 Xu J, Liu Z, Ornitz DM, Temporal and spatial gradients of Fgf8 and Fgf17 regulate proliferation and differentiation of midline cerebellar structures. Development. 2000 May;127(9):1833-43
1*	J:101025 Yaylaoglu MB, Titmus A, Visel A, Alvarez-Bolado G, Thaller C, Eichele G, Comprehensive expression atlas of fibroblast growth factors and their receptors generated by a novel robotic in situ hybridization platform. Dev Dyn. 2005 Oct;234(2):371-86
1	J:315014 Zhou C, Chen D, Ren J, Huang D, Li R, Luo H, Guan C, Cao Y, Wang W, FGF8 and BMP2 mediated dynamic regulation of dental mesenchyme proliferation and differentiation via Lhx8/Suv39h1 complex. J Cell Mol Med. 2021 Mar;25(6):3051-3062
1	J:316215 Zhou N, Li N, Liu J, Wang Y, Gao J, Wu Y, Chen X, Liu C, Xiao J, Persistent Wnt/beta-catenin signaling in mouse epithelium induces the ectopic Dspp expression in cheek mesenchyme. Organogenesis. 2019;15(1):1-12